Dr. Hossain was arrested during the Bangladesh Liberation War in April 1971 by the Pakistani Government and kept in custody in West Pakistan. He was released together with Sheikh Mujibur Rahman when both of them left Pakistan for London.
After East Pakistan earned its independence and became Bangladesh, Dr. Hossain served in the Government of Bangladesh under Sheikh Mujibur Rahman as the Minister of Law (1972–1973), Minister of Foreign Affairs (1973–1975) and Minister of Petroleum and Minerals (1974–1975). One of his earliest tasks as Minister of Law was the drafting of the Constitution of Bangladesh which was completed in 1972.
He was a member of the Awami League until the early 1990s, when he formed his own political party, Gano Forum (People's Forum), following disputes with Awami League leader Sheikh Hasina. Since leaving the Aw
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